COMPREHENSIVE STUDY OF SOME PLASMA BIOCHEMICAL PARAMETERS IN RELATIONTO BONE DISEASE IN HEMODIALYSIS PATIENTS IN ISFAHAN

The concentrations of serum calcitonin', parathormone (PTH), amylase, alkaline phosphatase (ALKP), calcium and phosphorus were studied in pre-and post-dialysis patients with chronic renal failure. All patients had extremely elevated serum urea and creatinine concentrations with the mean values of143.8 and 10.5 mg/dL respectively. The plasma amylase activity was higher than normal with a mean of 174 lUlL, but showed no significant changes following hemodialysis. The mean values for calcium and phosphorus in pre dialysis plasma were 7.2 and 7.5 mg/dL respectively, whereas it changed to 8.6 and 3.8 mgldL post-dialysis. The extent of increase in PTH and alkaline phosphatase levels depended on the duration of dialysis in the majority of the patients. The longer the period of the dialysis, the higher the concentrations of PTH and ALKP. On the basis of this study the relationship between bone disease and hemodialysis has been discussed.